Bisanz Lab Website Our mission is to understand how microbial diversity shapes host physiology.

All Publications

See our most up to date list of publications on google scholar.

2023

Main Manuscript for Microbiome single cell atlases generated with a benchtop instrument
Main Manuscript for Microbiome single cell atlases generated with a benchtop instrument
Xiangpeng Li, Linfeng Xu, Benjamin Demaree, Cecilia Noecker, Jordan E. Bisanz, Daniel W. Weisgerber, Cyrus Modavi, Peter J. Turnbaugh, Adam R. Abate
Cold Spring Harbor Laboratory   ·   10 Aug 2023   ·   doi:10.1101/2023.08.08.551713
Mild SARS-CoV-2 infection results in long-lasting microbiota instability
Mild SARS-CoV-2 infection results in long-lasting microbiota instability
Vaibhav Upadhyay, Rahul K. Suryawanshi, Preston Tasoff, Maria McCavitt-Malvido, Renuka G. Kumar, ..., Irene P. Chen, Susan V. Lynch, Melanie Ott, Sulggi Lee, Peter J. Turnbaugh
mBio   ·   09 Jun 2023   ·   doi:10.1128/mbio.00889-23
Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta
Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta
Cecilia Noecker, Juan Sanchez, Jordan E. Bisanz, Veronica Escalante, Margaret Alexander, ..., Yuanyuan Liu, Dylan Dodd, Ines Thiele, Brian C. DeFelice, Peter J. Turnbaugh
PLOS Biology   ·   19 May 2023   ·   doi:10.1371/journal.pbio.3002125
Roles of the gut microbiome in weight management
Roles of the gut microbiome in weight management
Rachel N. Carmody, Jordan E. Bisanz
Nature Reviews Microbiology   ·   03 May 2023   ·   doi:10.1038/s41579-023-00888-0
Challenges and opportunities of strain diversity in gut microbiome research
Challenges and opportunities of strain diversity in gut microbiome research
Benjamin D. Anderson, Jordan E. Bisanz
Frontiers in Microbiology   ·   17 Feb 2023   ·   doi:10.3389/fmicb.2023.1117122
Meta-organismal metabolism in cardiovascular disease
Meta-organismal metabolism in cardiovascular disease
Min Soo Kim, Jordan E. Bisanz
Cell Host & Microbe   ·   01 Jan 2023   ·   doi:10.1016/j.chom.2022.12.007

2022

Mild SARS-CoV-2 infection results in long-lasting microbiota instability
Mild SARS-CoV-2 infection results in long-lasting microbiota instability
Vaibhav Upadhyay, Rahul Suryawanshi, Preston Tasoff, Maria McCavitt-Malvido, G. Renuka Kumar, ..., Irene P. Chen, Susan V Lynch, Melanie Ott, Sulggi Lee, Peter J. Turnbaugh
Cold Spring Harbor Laboratory   ·   08 Dec 2022   ·   doi:10.1101/2022.12.07.519508
Making gut microbiomes from scratch
Making gut microbiomes from scratch
Shuchang Tian, Jordan E. Bisanz
Cell Host & Microbe   ·   01 Nov 2022   ·   doi:10.1016/j.chom.2022.10.005
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
Stephanie L. Collins, Jonathan G. Stine, Jordan E. Bisanz, C. Denise Okafor, Andrew D. Patterson
Nature Reviews Microbiology   ·   17 Oct 2022   ·   doi:10.1038/s41579-022-00805-x
Effects of caloric restriction on the gut microbiome are linked with immune senescence
Effects of caloric restriction on the gut microbiome are linked with immune senescence
Julia Sbierski-Kind, Sophia Grenkowitz, Stephan Schlickeiser, Arvid Sandforth, Marie Friedrich, ..., Peter J. Turnbaugh, Jordan E. Bisanz, Hans-Dieter Volk, Joachim Spranger, Reiner Jumpertz von Schwartzenberg
Microbiome   ·   04 Apr 2022   ·   doi:10.1186/s40168-022-01249-4
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
Donggi Paik, Lina Yao, Yancong Zhang, Sena Bae, Gabriel D. D’Agostino, ..., Clary B. Clish, Fraydoon Rastinejad, Curtis Huttenhower, Jun R. Huh, A. Sloan Devlin
Nature   ·   16 Mar 2022   ·   doi:10.1038/s41586-022-04480-z

2021

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome
Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome
Kathy N. Lam, Peter Spanogiannopoulos, Paola Soto-Perez, Margaret Alexander, Matthew J. Nalley, Jordan E. Bisanz, Renuka R. Nayak, Allison M. Weakley, Feiqiao B. Yu, Peter J. Turnbaugh
Cell Reports   ·   01 Nov 2021   ·   doi:10.1016/j.celrep.2021.109930
Reporting guidelines for human microbiome research: the STORMS checklist
Reporting guidelines for human microbiome research: the STORMS checklist
Chloe Mirzayi, Audrey Renson, Cesare Furlanello, Susanna-Assunta Sansone, Fatima Zohra, ..., Nicola Segata, Curtis Huttenhower, Jennifer B. Dowd, Heidi E. Jones, Levi Waldron
Nature Medicine   ·   01 Nov 2021   ·   doi:10.1038/s41591-021-01552-x
The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health
The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health
Qi Yan Ang, Diana L Alba, Vaibhav Upadhyay, Jordan E Bisanz, Jingwei Cai, ..., Grace Wei, Cecilia Noecker, Andrew D Patterson, Suneil K Koliwad, Peter J Turnbaugh
eLife   ·   07 Oct 2021   ·   doi:10.7554/eLife.70349
Caloric restriction disrupts the microbiota and colonization resistance
Caloric restriction disrupts the microbiota and colonization resistance
Reiner Jumpertz von Schwartzenberg, Jordan E. Bisanz, Svetlana Lyalina, Peter Spanogiannopoulos, Qi Yan Ang, ..., Andrew D. Patterson, Katherine S. Pollard, Knut Mai, Joachim Spranger, Peter J. Turnbaugh
Nature   ·   23 Jun 2021   ·   doi:10.1038/s41586-021-03663-4

2020

A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance
Kevin Man, Christopher Bowman, Kristina N. Braverman, Veronica Escalante, Yuan Tian, ..., Biao Wang, Andrew Patterson, James R. Bayrer, Peter J. Turnbaugh, Ajay Chawla
Proceedings of the National Academy of Sciences   ·   30 Nov 2020   ·   doi:10.1073/pnas.2012003117
Gut microbiota–specific IgA <sup>+</sup> B cells traffic to the CNS in active multiple sclerosis
Gut microbiota–specific IgA + B cells traffic to the CNS in active multiple sclerosis
Anne-Katrin Pröbstel, Xiaoyuan Zhou, Ryan Baumann, Sven Wischnewski, Michael Kutza, ..., Peter H. Seeberger, Jennifer L. Gommerman, Michael R. Wilson, Lucas Schirmer, Sergio E. Baranzini
Science Immunology   ·   13 Nov 2020   ·   doi:10.1126/sciimmunol.abc7191
Erratum: Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability
Erratum: Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability
R.A. Greenstein, Ramon R. Barrales, Nicholas A. Sanchez, Jordan E. Bisanz, Sigurd Braun, Bassem Al-Sady
Genes & Development   ·   01 Aug 2020   ·   doi:10.1101/gad.342006.120
A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria
A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria
Jordan E. Bisanz, Paola Soto-Perez, Cecilia Noecker, Alexander A. Aksenov, Kathy N. Lam, ..., Suzanne Devkota, Emily P. Balskus, Pieter C. Dorrestein, Emma Allen-Vercoe, Peter J. Turnbaugh
Cell Host & Microbe   ·   01 Jun 2020   ·   doi:10.1016/j.chom.2020.04.006
A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
Vayu Maini Rekdal, Paola Nol Bernadino, Michael U Luescher, Sina Kiamehr, Chip Le, Jordan E Bisanz, Peter J Turnbaugh, Elizabeth N Bess, Emily P Balskus
eLife   ·   18 Feb 2020   ·   doi:10.7554/eLife.50845

2019

Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability
Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability
R.A. Greenstein, Ramon R. Barrales, Nicholas A. Sanchez, Jordan E. Bisanz, Sigurd Braun, Bassem Al-Sady
Genes & Development   ·   05 Dec 2019   ·   doi:10.1101/gad.328468.119
Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria
Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria
Elizabeth N. Bess, Jordan E. Bisanz, Fauna Yarza, Annamarie Bustion, Barry E. Rich, ..., Stephen Nayfach, Suneil K. Koliwad, Dennis W. Wolan, Adrian A. Franke, Peter J. Turnbaugh
Nature Microbiology   ·   04 Nov 2019   ·   doi:10.1038/s41564-019-0596-1
Cooking shapes the structure and function of the gut microbiome
Cooking shapes the structure and function of the gut microbiome
Rachel N. Carmody, Jordan E. Bisanz, Benjamin P. Bowen, Corinne F. Maurice, Svetlana Lyalina, ..., Kylynda C. Bauer, Thomas W. Balon, Katherine S. Pollard, Trent R. Northen, Peter J. Turnbaugh
Nature Microbiology   ·   30 Sep 2019   ·   doi:10.1038/s41564-019-0569-4
CRISPR-Cas System of a Prevalent Human Gut Bacterium Reveals Hyper-targeting against Phages in a Human Virome Catalog
CRISPR-Cas System of a Prevalent Human Gut Bacterium Reveals Hyper-targeting against Phages in a Human Virome Catalog
Paola Soto-Perez, Jordan E. Bisanz, Joel D. Berry, Kathy N. Lam, Joseph Bondy-Denomy, Peter J. Turnbaugh
Cell Host & Microbe   ·   01 Sep 2019   ·   doi:10.1016/j.chom.2019.08.008
Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Evan Bolyen, Jai Ram Rideout, Matthew R. Dillon, Nicholas A. Bokulich, Christian C. Abnet, ..., Jesse R. Zaneveld, Yilong Zhang, Qiyun Zhu, Rob Knight, J. Gregory Caporaso
Nature Biotechnology   ·   09 Aug 2019   ·   doi:10.1038/s41587-019-0252-6
Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass
Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass
D. Nyasha Chagwedera, Qi Yan Ang, Jordan E. Bisanz, Yew Ann Leong, Kirthana Ganeshan, Jingwei Cai, Andrew D. Patterson, Peter J. Turnbaugh, Ajay Chawla
Cell Metabolism   ·   01 Aug 2019   ·   doi:10.1016/j.cmet.2019.05.002
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Jordan E. Bisanz, Vaibhav Upadhyay, Jessie A. Turnbaugh, Kimberly Ly, Peter J. Turnbaugh
Cell Host & Microbe   ·   01 Aug 2019   ·   doi:10.1016/j.chom.2019.06.013
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Evan Bolyen, Jai Ram Rideout, Matthew R. Dillon, Nicholas A. Bokulich, Christian C. Abnet, ..., Jesse R. Zaneveld, Yilong Zhang, Qiyun Zhu, Rob Knight, J. Gregory Caporaso
Nature Biotechnology   ·   24 Jul 2019   ·   doi:10.1038/s41587-019-0209-9
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Vayu Maini Rekdal, Elizabeth N. Bess, Jordan E. Bisanz, Peter J. Turnbaugh, Emily P. Balskus
Science   ·   14 Jun 2019   ·   doi:10.1126/science.aau6323

2018

Immobilization of cadmium and lead by <i>Lactobacillus rhamnosus</i> GR-1 mitigates apical-to-basolateral heavy metal translocation in a Caco-2 model of the intestinal epithelium
Immobilization of cadmium and lead by Lactobacillus rhamnosus GR-1 mitigates apical-to-basolateral heavy metal translocation in a Caco-2 model of the intestinal epithelium
Brendan A. Daisley, Marc Monachese, Mark Trinder, Jordan E. Bisanz, John A. Chmiel, Jeremy P. Burton, Gregor Reid
Gut Microbes   ·   14 Nov 2018   ·   doi:10.1080/19490976.2018.1526581
How to Determine the Role of the Microbiome in Drug Disposition
How to Determine the Role of the Microbiome in Drug Disposition
Jordan E. Bisanz, Peter Spanogiannopoulos, Lindsey M. Pieper, Annamarie E. Bustion, Peter J. Turnbaugh
Drug Metabolism and Disposition   ·   15 Aug 2018   ·   doi:10.1124/dmd.118.083402
Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins
Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins
Nitzan Koppel, Jordan E Bisanz, Maria-Eirini Pandelia, Peter J Turnbaugh, Emily P Balskus
eLife   ·   15 May 2018   ·   doi:10.7554/eLife.33953
Evaluation of sampling and storage procedures on preserving the community structure of stool microbiota: A simple at-home toilet-paper collection method
Evaluation of sampling and storage procedures on preserving the community structure of stool microbiota: A simple at-home toilet-paper collection method
Kait F. Al, Jordan E. Bisanz, Gregory B. Gloor, Gregor Reid, Jeremy P. Burton
Journal of Microbiological Methods   ·   01 Jan 2018   ·   doi:10.1016/j.mimet.2017.11.014

2017

Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
Ruth M Harvie, Alexandra W Chisholm, Jordan E Bisanz, Jeremy P Burton, Peter Herbison, Kim Schultz, Michael Schultz
World Journal of Gastroenterology   ·   01 Jan 2017   ·   doi:10.3748/wjg.v23.i25.4632

2016

The oral microbiome of patients with axial spondyloarthritis compared to healthy individuals
The oral microbiome of patients with axial spondyloarthritis compared to healthy individuals
Jordan E. Bisanz, Praema Suppiah, W. Murray Thomson, Trudy Milne, Nigel Yeoh, ..., Gregor Reid, Gregory B. Gloor, Jeremy P. Burton, Mary P. Cullinan, Simon M. Stebbings
PeerJ   ·   09 Jun 2016   ·   doi:10.7717/peerj.2095

2015

A multi-platform metabolomics approach identifies highly specific biomarkers of bacterial diversity in the vagina of pregnant and non-pregnant women
A multi-platform metabolomics approach identifies highly specific biomarkers of bacterial diversity in the vagina of pregnant and non-pregnant women
Amy McMillan, Stephen Rulisa, Mark Sumarah, Jean M. Macklaim, Justin Renaud, Jordan E. Bisanz, Gregory B. Gloor, Gregor Reid
Scientific Reports   ·   21 Sep 2015   ·   doi:10.1038/srep14174
Microbiota at Multiple Body Sites during Pregnancy in a Rural Tanzanian Population and Effects of Moringa-Supplemented Probiotic Yogurt
Microbiota at Multiple Body Sites during Pregnancy in a Rural Tanzanian Population and Effects of Moringa-Supplemented Probiotic Yogurt
Jordan E. Bisanz, Megan K. Enos, George PrayGod, Shannon Seney, Jean M. Macklaim, ..., Christoph Fusch, Gerhard Fusch, Gregory B. Gloor, Jeremy P. Burton, Gregor Reid
Applied and Environmental Microbiology   ·   01 Aug 2015   ·   doi:10.1128/AEM.00780-15

2014

Randomized Open-Label Pilot Study of the Influence of Probiotics and the Gut Microbiome on Toxic Metal Levels in Tanzanian Pregnant Women and School Children
Randomized Open-Label Pilot Study of the Influence of Probiotics and the Gut Microbiome on Toxic Metal Levels in Tanzanian Pregnant Women and School Children
Jordan E. Bisanz, Megan K. Enos, Joseph R. Mwanga, John Changalucha, Jeremy P. Burton, Gregory B. Gloor, Gregor Reid
mBio   ·   31 Oct 2014   ·   doi:10.1128/mBio.01580-14
A Systems Biology Approach Investigating the Effect of Probiotics on the Vaginal Microbiome and Host Responses in a Double Blind, Placebo-Controlled Clinical Trial of Post-Menopausal Women
A Systems Biology Approach Investigating the Effect of Probiotics on the Vaginal Microbiome and Host Responses in a Double Blind, Placebo-Controlled Clinical Trial of Post-Menopausal Women
Jordan E. Bisanz, Shannon Seney, Amy McMillan, Rebecca Vongsa, David Koenig, ..., Mark Sumarah, Brenda Ford, Dorli Herman, Jeremy P. Burton, Gregor Reid
PLoS ONE   ·   15 Aug 2014   ·   doi:10.1371/journal.pone.0104511

2013

The Rationale for Probiotics Improving Reproductive Health and Pregnancy Outcome
The Rationale for Probiotics Improving Reproductive Health and Pregnancy Outcome
Jennifer N. S. Reid, Jordan E. Bisanz, Marc Monachese, Jeremy P. Burton, Gregor Reid
American Journal of Reproductive Immunology   ·   18 Feb 2013   ·   doi:10.1111/aji.12086

2011

Vaginal Microbiome and Epithelial Gene Array in Post-Menopausal Women with Moderate to Severe Dryness
Vaginal Microbiome and Epithelial Gene Array in Post-Menopausal Women with Moderate to Severe Dryness
Ruben Hummelen, Jean M. Macklaim, Jordan E. Bisanz, Jo-Anne Hammond, Amy McMillan, Rebecca Vongsa, David Koenig, Gregory B. Gloor, Gregor Reid
PLoS ONE   ·   02 Nov 2011   ·   doi:10.1371/journal.pone.0026602
Unraveling How Probiotic Yogurt Works
Unraveling How Probiotic Yogurt Works
Jordan E. Bisanz, Gregor Reid
Science Translational Medicine   ·   26 Oct 2011   ·   doi:10.1126/scitranslmed.3003291

2010

Probiotic strategies for the treatment and prevention of bacterial vaginosis
Probiotic strategies for the treatment and prevention of bacterial vaginosis
Roderick A MacPhee, Ruben Hummelen, Jordan E Bisanz, Wayne L Miller, Gregor Reid
Expert Opinion on Pharmacotherapy   ·   17 Nov 2010   ·   doi:10.1517/14656566.2010.512004